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New Studies Reveal Effects of Testosterone Therapy

Two recent studies have shed some light on the effects that testosterone replacement therapies have on men. In particular, the studies revealed that exercise and obesity significantly impact the success rate of testosterone replacement therapy.

Dr. Min Gu Park from Inje University in South Korea conducted a study, which demonstrated that exercise may influence the positive effects of testosterone therapy. His study consisted of 50 men with late-onset hypogonadism (i.e., low testosterone). The subjects were divided into two groups and each group received testosterone replacement therapy over a 12-week period followed by eight weeks without receiving any treatment. The first group of subjects received an exercise program while the second group of subjects did not. The first group’s exercise regimen consisted of 90 minutes aerobic, strength, and stretching exercises for at least 3 days a week over the 12-week period. The results revealed that while both groups had an increase in testosterone levels, the exercise group showed significantly higher levels. The findings also demonstrated that the improvement of testosterone levels could be maintained with continuous exercise after testosterone treatments have ended.

Another study conducted by Cornell Medical College revealed that men with diabetes and obesity have a lower success rate with testosterone treatment than other men who have clinically labeled non-obese body mass indexes (BMI). The study included 58 participants. Of those patients, 32 had a BMI rating that labeled them non-obese while 26 men were obese. All the subjects were similar in age and had about the same baseline hormone levels at the start of the study. The subjects also had similar symptoms associated with low testosterone, such as low sex drive and erectile dysfunction. The subjects received one out of three commercial transdermal testosterone replacements over 18 to 24 months. By the end of the study, findings showed 81% of the non-obese men achieved normal testosterone levels and 52% of the obese men achieved normal levels. Dr. Tobias Kohler, associate professor and residency program director at Southern Illinois University School of Medicine, concluded that “as these studies show, not all men may be good candidates for this therapy.”

Other medical professional criticize low testosterone replacement therapies. Dr. Ajay Nangia, Professor of Urology at the University of Kansas, states that doctors and patients rely too much on testosterone products to deal with issues like low libido and infertility. Dr. Nangia adds, “there are some legitimate concerns about testosterone therapy,” so there is a need for more research and studies to be conducted to learn more about them.

These worries follow the FDA’s January 31, 2014 Safety Announcement that it will investigate the cardiovascular risks associated with testosterone therapy after growing concern that these drugs may be linked to increased risk of blood clots, heart attack, and stroke, as demonstrated by published studies. The first study that prompted FDA’s Safety Announcement was published in the Journal of the American Medical Association (JAMA) in November 2013 and suggested that testosterone replacement drugs may increase the risk of heart attack, stroke and death. The study followed more than 8,000 male veterans with low testosterone. After comparing cardiovascular events in males taking a testosterone supplement with those who were not taking such supplements, the study concluded that men who used a supplement were 29% more likely to die, have a heart attack, or experience a stroke within three years of use. This was the result even after considering various factors that contribute to cardiovascular illnesses, such as age, blood pressure, and existing heart disease. The second study that prompted FDA’s Safety Announcement was published in the online journal PLos ONE on January 29, 2014, and concluded that older men, and younger men with pre-existing diagnosed heart disease, have an increased risk of heart attack following initiation of testosterone therapy. In particular, the study reported that men ages 65 years or older have a two-fold increase in the risk of heart attack in the first 90 days following the first prescription of testosterone therapy. And among younger men less than 65 years of age who have a pre-existing history of heart disease, the study reported a two- to three-fold increased risk of heart attack in the first 90 days following the first prescription of testosterone therapy.

The attorneys at Schlichter, Bogard & Denton, LLP are offering a free case review with no further obligation to those who have suffered injuries after using testosterone therapy. If you suffered injuries after using testosterone therapy, please contact the attorneys at Schlichter, Bogard & Denton, LLP toll-free at 1-800-873-5297 for your confidential and free consultation.


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