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MDL 2404 Update: Nexium® Lawsuits on the Rise

On December 6, 2012, lawsuits filed in federal court against the manufacturers of Nexium® were consolidated by the Judicial Panel on Multidistrict Litigation (JPML) in order to coordinate federal judicial proceedings. This Multidistrict Litigation (MDL) is entitled In re: Nexium® (Esomeprazole) Products Liability Litigation (MDL 2404) and is currently pending in the United States District Court for the Central District of California before The Honorable Judge Dale S. Fischer.

The number of Nexium® lawsuits in the Multidistrict Litigation have grown since the date of original consolidation. To date, there are approximately 47 Nexium® lawsuits pending in MDL 2404. The increasing number of such lawsuits is indicative of the serious injuries that individuals have sustained while taking Nexium®.

Nexium is a proton pump inhibitor (PPI) designed to treat acid reflux disease by inhibiting excessive acid secretion. Plaintiffs allege that Nexium® may cause several bone ailments—including osteoporosis, loss of bone density, and bone fractures—and accuse AstraZeneca, the drug’s manufacturer, of failing to warn users of these potential adverse effects.

In 2010, the FDA issued a warning about these possible complications associated with Nexium®. In 2011, the Annals of Family Medicine released a study in which researchers found that patients taking Nexium® for long-term usage were 30% more likely to suffer bone fractures than patients who did not. In January 2012, a study published in the British Medical Journal concluded that postmenopausal women are at a 35% increased risk of hip fractures if they regularly use proton pump inhibitor drugs, including Nexium®, and that risk increases to more than 50% among women with a history of smoking. In April 2012, the Medicines and Healthcare Products Regulatory Agency (MHRA) issued an article revealing that there is recent epidemiological evidence of an increased risk of fracture with long-term use of proton pump inhibitors, including Nexium®.


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