Tuesday, June 16, 2009

Skin Cancer Drug Increases Collagen Production and Smoothes Wrinkles

In a U.S. study released today, researchers found that a cream used to treat the early signs of skin cancer may erase wrinkles and leave behind younger- looking skin. Researchers say Valeant Pharmaceuticals’’ cream Efudex, which is used to treat actinic keratoses, a precancerous form of squamous cell carcinoma, improved the appearance of skin. Efudex apparently smoothes out rough spots and wrinkles, while improving skin color, and erasing brown spots. The cream appears to cause a wound healing response that leads to an increase in collagen production, which improves the appearance of wrinkles.

The study was performed on 21 individuals, aged 56 to 85, with actinic keratoses and sun damage. The volunteers used the cream twice daily on the face for two weeks Researchers measured changes in the skin by taking facial biopsies over a six-month period. The drug had a significant effect, causing people’s skin to be much softer. The researchers also noticed that skin appeared to be less yellow and more even toned with fewer brown spots.

However, treatment with Efudex, known as fluorouracil, is not trouble free. According to Dr. Dana Sachs of the University of Michigan, shortly after the cream is applied, the skin becomes red and inflamed. “Patients look really bad. Their skin is red. I’ve had people describe it as looking law raw hamburger meat.”

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posted by Chavon Williams at 12:48 PM

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